The discovery of Hoogsteen base pairs, an alternative pairing mode to the canonical Watson–Crick structure, has significantly broadened our understanding of DNA dynamics. This conformation, in which ...

Erwin Chargaff's groundbreaking research, which showed that DNA base pairs had a complementary relationship, laid the foundation for James Watson's and Francis Crick's DNA model. When word spread that ...

Metal-mediated base pairing in nucleic acids represents a transformative approach wherein traditional Watson–Crick hydrogen bonds are replaced or supplemented by coordinate bonds with metal ions. This ...

This image illustrates the chemical structures of the five main nucleobases found in DNA and RNA. The pyrimidines, thymine (DNA), uracil (RNA), and cytosine are shown on top while the purines, adenine ...

DNA is the genetic material used by every living organism. But, in a few edge cases, the four bases of DNA—adenine, thymidine, cytosine, and guanine—undergo chemical modifications. And in viruses, ...