The mechanism of action of artemisinin and its derivatives, the most potent of the anti-malarial drugs, is not completely understood. Here we present an unbiased chemical proteomics analysis to ...
Fumarate hydratase (FH), an enzyme in the tricarboxylic acid (TCA) cycle, is mutated in the germline of patients with hereditary leiomyomatosis and renal cell cancer (HLRCC). This mutation results in ...