Apoptosis is a form of non-lytic programmed cell death that is important as a driver of normal development, for cell population maintenance, and as a defense mechanism in immune reactions or in ...

Middle East respiratory syndrome (MERS) is associated with a mortality rate of >35%. We previously showed that MERS coronavirus (MERS-CoV) could infect human macrophages and dendritic cells and induce ...

Apoptosis is a highly regulated and critical homeostatic process in multicellular organisms. Aberrations in this form of programmed cell death have been implicated in several pathological conditions ...

Up to the 1980s, cell death caused by drugs, chemicals, and other pathophysiologies was primarily considered necrosis. This view radically changed with the discovery of apoptosis and its specific ...

Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex that ...