Most cells in the human body carry the entire genome within their nucleus, and as cells divide, age, or are exposed to environmental stresses like UV rays, the DNA in that nucleus can become damaged.

Micronuclei, which are small nucleus-like structures within cells, are commonly associated with tumors. Now, researchers from Tsukuba, Japan have developed an automated computer program that can ...

Numerous errors in chromosome segregation during cell division can lead to the formation of micronuclei, even if there isn’t actual mis-segregation of the chromosomes. These events are not mutually ...

Chromothripsis enables cancer cells to evolve and resist treatment. With their new findings, researchers hope to explore ways ...

Researchers have created a novel automated program that accurately and quickly counts micronuclei in stained images. Micronuclei are small nucleus-like structures that are markers of pathologies such ...

The induction of micronuclei is a key characteristic of genotoxic compounds; for example, clastrogens produce DNA strand breakage while aneugens interfere with chromosome segregation. As a result, ...

B. M. Miller, T. Werner, H.-U. Weier and M. Nüsse Fluorescence in situ hybridization using simultaneously a combination of DNA probes for the telomeric hexamer repeat (TTAGGG) and the centromerically ...

In 2022, on the alpine shores of Lake Maggiore in northern Italy, longtime friends Samuel Bakhoum, M.D., Ph.D., and Stefano Santaguida, Ph.D., were catching up. Pandemic restrictions had prevented the ...

University of California San Diego researchers have discovered the enzyme responsible for chromothripsis, a process in which a single chromosome is shattered into pieces and rearranged in a scrambled ...

Cancer’s most catastrophic DNA damage has long looked like a crime scene without a culprit, with chromosomes shattered and ...