The heterodimeric nuclear factor (NF) 90/NF45 complex (NF90/NF45) binds nucleic acids and is a multifunctional regulator of gene expression. Here we report that depletion of NF90/NF45 restores the ...

ING1b is a tumor suppressor that affects transcription, cell cycle control and apoptosis. ING1b is deregulated in disease, and its activity is closely linked to that of p53. In addition to regulating ...

Kit p21 SimpleStep ELISA ® kit Quantitatively measure p21 in human cell and tissue extracts. Get fast, reproducible results in 90 minutes. Abcam is a global life sciences company providing highly ...

Ischemia is a significant loss of blood supply that can affect any tissue. Such decrease in the supply of blood results in oxygen deprivation preventing effective cellular metabolism and can bring ...

The cell cycle represents a series of tightly integrated events that allow the cell to grow and proliferate. An essential part of the cell cycle machinery is the cyclin-dependent kinases (CDKs). When ...

Edited by Steven Benowitz R.A. Steinman, B. Hoffman, A. Iro, C. Guillouf, D.A. Liebermann, M.E. Elhouseini, "Induction of p21 (WAF1/CIP1) during differentiation ...

The cover for issue 37 of Oncotarget features Figure 7, "The combination of romidepsin and KU60019 is synergistic in a xenograft model of MCL," by Scotto, et al. which reported that the ...

The cover for issue 37 of Oncotarget features Figure 7, "The combination of romidepsin and KU60019 is synergistic in a xenograft model of MCL," by Scotto, et al. which reported that the ...