Resistance to apoptosis plays a critical role during tumorigenesis and tumour progression, facilitating the accumulation of transforming mutations, promoting evasion of tumour cells from ...

The researchers -- led by Xiaodong Wang, a Howard Hughes Medical Institute investigator at the University of Texas Southwestern Medical Center at Dallas and his colleagues Patrick Harran and Jef De ...

Application of artificial intelligence to predict a new class of novel synthetic lethal targets. This is an ASCO Meeting Abstract from the 2019 ASCO Annual Meeting I. This abstract does not include a ...

When used as monotherapy against tumors, small molecules that mimic the SMAC protein and thereby inhibit apoptosis are ineffective. The same is true for inhibitors of BET family proteins. If each ...

Howard Hughes Medical Institute researchers have developed a small molecule that can turn the survival signal for a variety of cancer cells into a death signal. The molecule mimics the activity of ...

MALVERN, Pa., Dec. 11, 2011 /PRNewswire/ -- TetraLogic Pharmaceuticals, a biopharmaceutical company developing novel small molecule Smac mimetic drugs to treat cancer, today announced the oral ...

Minocycline is broadly protective in neurologic disease models featuring cell death and is being evaluated in clinical trials. We previously demonstrated that minocycline-mediated protection against ...

TetraLogic Closes $6 Million Series C-1 Investment with Nextech Invest Ltd. $43 Million Raised in Past Year to Complete Phase 2a Cancer Clinical Studies- MALVERN, Pa., May 24, 2011 /PRNewswire/ -- ...