This image illustrates the process of gene transcription within a cell. The DNA double helix unwinds to expose a specific sequence, allowing RNA polymerase to synthesize a complementary pre-mRNA ...

The human genome contains approximately 1,600 types of transcription factors responsible for regulating gene activity across ...

Bacteria need to constantly adapt to compete against other species for nutrient sources and to survive against threats such as antibiotics and toxins. In an effort to understand how bacteria control ...

The carboxy-terminal domain (CTD) of RNA polymerase II (Pol II) is composed of repeats of the heptapeptide Tyr-Ser-Pro-Thr-Ser-Pro-Ser and is dynamically post-translationally modified to regulate ...

Biophysicists have provided new insight into the mechanisms of gene transcription. They developed a computer model to simulate how the transcription of RNA from DNA is initiated and demonstrate the ...

Gene regulation underpins nearly every biological process—from cell development to responses to environmental changes, and understanding it can provide insights into cancer and other diseases. Now, ...

Researchers at University of Tsukuba have comprehensively analyzed genomic binding data of transcription factors (proteins that regulate gene expression) in humans, revealing a substantial amount of ...