Dec 5, 2013 · Peripheral sensitization contributes to pain hypersensitivity found at the location of tissue damage and/or inflammation. The chapter reviews the events that underlie pain as well as the …

Dec 10, 2009 · Two processes contribute to hyperalgesia and allodynia: peripheral sensitization of nociceptors, where events around the damaged site combine to allow a lower intensity stimulus to …

In general terms, both central and peripheral chronic pain syndromes have similar characteristics. These include evidence of sensory loss, ongoing pain and pain evoked by stimuli that are not normally …

Sep 1, 1997 · This target article examines the clinical and experimental evidence for a role of peripheral and central hyperexcitability in persistent pain in four key areas: cutaneous hyperalgesia, referred …

In addition, the injury-induced structural changes in peripheral afferent 29 and sympathetic nerves 30, 31 and in higher brain structures are almost certainly irreversible. 12 These enduring changes also …

The Essence of Analgesia and Analgesics - October 2010

Rueff, A., and Dray, A.1992. 5-Hydroxytryptamine-induced sensitization and activation of peripheral fibres in the neonatal rat are mediated via different 5-hydroxytryptamine-receptors.

A number of neurochemicals (e.g. substance P, 5-HT) are involved in the activation of these peripheral endings by noxious stimulation or in their peripheral sensitization; the sensitivity of the endings may …

Jun 5, 2012 · Magnesium plays an important role in the prevention of central sensitization and in the attenuation of established pain hypersensitivity, and its main mode of action appears to involve its …

Over the past two decades, a convergence of basic and clinical evidence has established the neuropeptide calcitonin-gene-related peptide (CGRP) as a key player in migraine. Although CGRP is …